Abstract: The effect of regional socio-economic features of the destination of floating population is paid rarely attention in literatures on migration in China. Based on the data of 2015 National Migrants Dynamic Monitoring Survey and relevant statistical yearbooks, this paper discusses the regional determinants (socio-economic features) of the residential intention of floating population in destination place, with hierarchical binominal/multinomial logistic regression model controlling the features at individual and family level. Results of hierarchical model indicate that the regional socio-economic features of the destination play different important role in the individual-level residential intention in various ways. The regional economic features make the effect on the residential intention of floating population by the means of the individual-level education, income, and whether living together with spouses at family level. However, the effect of the regional social features on the residential intention of floating population, to some extent, is ineffective. And, the rise of the individual-level socio-economic status, and living with spouses at family-level, will significantly promote the residential intention of floating population. We conclude that the residential intention of floating population is a rational decision made by individual and family based on the interaction between the individual/family characteristics and the regional-level socio-economic development features of the destination.